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M94A2624.TXT
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1994-10-25
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Document 2624
DOCN M94A2624
TI Pentamidine pharmacokinetics in a neonate and his mother with AIDS.
DT 9412
AU Schwebke K; Fletcher C; Acousta E; Henry K; St. Paul-Ramsey Medical
Center, Minn.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):261 (abstract no. PB0473). Unique
Identifier : AIDSLINE ICA10/94369951
AB OBJECTIVE: To describe pentamidine pharmacokinetics in a woman with AIDS
and her newborn infant while the mother was receiving treatment for
Pneumocystis carinii pneumonia (PCP). METHODS: (Case Report): A
21-year-old HIV seropositive female who was 32 weeks pregnant was
hospitalized with PCP (CD4 count = 196). TMP-SMZ was stopped due to
adverse events and she was placed on i.v. pentamidine 200mg each day
(weight = 58.1 kg). Due to progressive worsening of the mother's medical
status, the neonate was delivered by C-section. Blood specimens for
pentamidine concentration were sent that day from the mother and neonate
(cord blood). RESULTS: The mother's pentamidine concentration 8 hours
after her 7th dose was 81.3 mcg/L (a simulation model predicted 3-76
mcg/L). The infant's concentration drawn 16.5 hours after the mother's
7th dose was 13.2 mcg/L (Table 1). CONCLUSION: Present knowledge of the
pharmacokinetics of placental transfer of antimicrobial agents used in
the treatment of HIV/AIDS related infections is very limited. Data
regarding placental transfer of pentamidine is limited to data from in
vitro or animal models. In this report, in vivo placental transfer of
pentamidine was observed. Networks to further study maternal-fetal
pharmacokinetics of medications used in the treatment and prophylaxis of
HIV-related complications need to be established.
DE Acquired Immunodeficiency Syndrome/*BLOOD/DRUG THERAPY/ TRANSMISSION
Adult AIDS-Related Opportunistic Infections/*BLOOD/DRUG THERAPY/
TRANSMISSION Case Report Cesarean Section Female Fetal
Blood/*METABOLISM Human Infant, Newborn Infusions, Intravenous
Maternal-Fetal Exchange/*PHYSIOLOGY Metabolic Clearance Rate/PHYSIOLOGY
Pentamidine/ADMINISTRATION & DOSAGE/*PHARMACOKINETICS Pneumonia,
Pneumocystis carinii/*BLOOD/DRUG THERAPY/TRANSMISSION Pregnancy
Pregnancy Complications, Infectious/*BLOOD/DRUG THERAPY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).